Glucocorticoid receptor-IN-2 (Compound WX019) is a selective glucocorticoid receptor (GR) modulator with anti-inflammatory effect. Glucocorticoid receptor-IN-2 exhibits very good transcriptional repressive activity with an IC 50 of 0.171 nM against hMMP1 , and comparable transcriptional activation activity with an EC 50 of 0.94 nM against MMTV.