GSK-3β inhibitor 23 (Compound 11726169) is the inhibitor for glycogen synthase kinase-3 , that inhibits GSK-3β and GSK-3α with IC 50 of 12.1 nM and 18.8 nM. GSK-3β inhibitor 23 exhibits antiviral activity against HIV 1. GSK-3β inhibitor 23 exhibits good metabolic stablility in mouse/human liver microsomes and plasma, but poor Caco-2 permeability (which predicts low oral bioavailability).