加拉碘铵, 肌肉型烟碱乙酰胆碱受体拮抗剂

AChR 抑制剂

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货号 (SKU)	包装规格	是否现货	价格	数量
G408368-1ml	1ml	现货

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Compound libraries (12332)

基本描述

英文别名	2,2',2''-[1,2,3-benzenetriyltris(oxy)]tris[N,N,N-triethyl-ethanaminium, iodide (1:3)
规格或纯度	Moligand™, 10mM in DMSO
英文名称	Gallamine Triethiodide
生化机理	加拉碘铵是一种胆碱能受体阻断剂，其 IC50 值为 68.0 ± 8.4 μM。
储存温度	-80℃储存
运输条件	超低温冰袋运输
作用类型	拮抗剂
作用机制	肌肉型烟碱乙酰胆碱受体拮抗剂
产品介绍	Gallamine Triethiodide是胆碱能受体抑制剂和非去极化阻断剂，IC50为68.0±8.4 μM。Gallamine Triethiodide is a synthetic nondepolarizing blocking drμg. Target: mAChR Gallamine triethiodide is a non-depolarising muscle relaxant. It acts by combining with the cholinergic receptor sites in muscle and competitively blocking the transmitter action of acetylcholine. Gallamine triethiodide has a parasympatholytic effect on the cardiac vagus nerve which causes tachycardia and occasionally hypertension. Very high doses cause histamine release. Gallamine triethiodide is commonly used to stabilize muscle contractions during surgical procedures. From Wikipedia. Information Gallamine Triethiodide Gallamine Triethiodide is a cholinergic receptor blocker with an IC50 of 68.0 ± 8.4 μM. In vitro In vivo Cell Data cell lines： Concentrations： Incubation Time： Powder Purity:≥97%

CHRNA1 Tclin 乙酰胆碱受体亚基α(Acetylcholine receptor subunit alpha) (1 活性数据)

点击查看靶蛋白信息： CHRNA1

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

CHRM2 Tclin 毒蕈碱乙酰胆碱受体 M2(Muscarinic acetylcholine receptor M2) (1 活性数据)

点击查看靶蛋白信息： CHRM2

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

Canonical SMILES	[I-].[I-].[I-].CC[N+](CC)(CC)CCOC1=C(OCC[N+](CC)(CC)CC)C(=CC=C1)OCC[N+](CC)(CC)CC
分子量	891.53

Concentration(Compounding value)	9-11(mmol/L)
Record the entire process by video	Conform

C of A & Other Certificates(BSE/TSE, COO):

输入批号以搜索分析图谱:

1. Lin Huang, Weixia Zhang, Difei Tong, Lingzheng Lu, Weishang Zhou, Dandan Tian, Guangxu Liu, Wei Shi. (2023) Triclosan and triclocarban weaken the olfactory capacity of goldfish by constraining odorant recognition, disrupting olfactory signal transduction, and disturbing olfactory information processing. WATER RESEARCH, 233 (119736). [PMID:36801581] [10.1016/j.watres.2023.119736]

1. Lin Huang, Weixia Zhang, Difei Tong, Lingzheng Lu, Weishang Zhou, Dandan Tian, Guangxu Liu, Wei Shi. (2023) Triclosan and triclocarban weaken the olfactory capacity of goldfish by constraining odorant recognition, disrupting olfactory signal transduction, and disturbing olfactory information processing. WATER RESEARCH, 233 (119736). [PMID:36801581] [10.1016/j.watres.2023.119736]