Gold nanoparticles (AuNPs) ranging from 2-200nm in diameter find applications in diverse fields.They show excellent biocompatibility and attractive physicochemical properties. Poly (ethylene) glycol (PEG) surface coatings on gold nanoparticles help in the reduction of protein adsorption, reduce nonspecific interactions with cells and greatly improve the pharmokinetics of these nanoparticles and reduce aggregation of the nanoparticles. PEG layer density depends inversely on the AuNP curvature. Denser coatings are possible on smaller AuNPs. The methyl group, being hydrophobic, acts as a protecting shield between the gold nanoparticles and the hydrophilic outer PEG coating and also leads to a further reduction of protein adsorption and macrophage uptake by the AuNPs.Several other specific applications have been listed below:Since they adhere to cell membranes, AuNPs may find use in cellular and intracellular targeting in targeted drug delivery applications and may also used in biodistribution studies.AuNPs may also be used in photothermal therapy and radiotherapy.AuNPs ranging from 10 to 250 nm, were studied to have been absorbed primarily by liver and spleen , when injected intravenously in rats.Whereas, 10 nm nanoparticles were distributed more broadly into various organs.Functionalized Particles have been extensively used to study cellular uptake of nanoparticles and targeted drug delivery.

Description

规格

英文别名

Au NP OMe, Gold nanoparticles OMe terminated, Gold Colloid

规格或纯度

直径15 nm,甲基封端,PEG 2000涂层,外径50,在H₂O中分散

英文名称

Gold nanoparticles

储存条件

2-8°C储存

运输条件

低温运输

名称和识别符

分子类型

小分子

高级数据

化学和物理性质

溶解性

水：混溶

密度

1.00g/cm³

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溶液计算器