计算溶液所需的质量、体积或浓度。
为什么选择此级别
，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
-80℃储存。特低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
概述
GSK-3β inhibitor 3 is a potent, selective, irreversible and covalent inhibitor of Glycogen Synthase Kinase 3β (GSK-3β) , with an IC 50 of 6.6 μM. GSK-3β inhibitor 3 can be used for the research of acute promyelocytic leukemia
In Vitro
GSK-3β inhibitor 3 (compound 4-3) (100 μM) inhibits GSK-3α activity by 87.3%. GSK-3β inhibitor 3 (6.25-100 μM; 24-48 h) dose-dependently inhibits the growth of NB4 and NB4-R1 cells. GSK-3β inhibitor 3 (12.5-100 μM; 24 h) significantly increases the percentage of apoptosis in a dose-dependent pattern in NB4 and NB4-R1 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: NB4 and NB4-R1 cells Concentration: 6.25, 12.5, 25, 50, 100 μM Incubation Time: 24, 48 hours Result: Inhibited the cell viability, with IC 50 s of 19.56 μM and 26.42 μM in NB4 and NB4-R1 cells at 24 h, respectively. Had little cytotoxicity on human normal liver cells (LO 2 ) and human umbilical vein endothelial cells (HUVECs). Apoptosis AnalysisCell Line: NB4 and NB4-R1 cells Concentration: 12.5, 25, 50, 100 μM Incubation Time: 24 hours Result: Induced cell apoptosis.
In Vivo
GSK-3β inhibitor 3 (compound 4-3) (15 mg/kg/d; i.p. for 2 weeks) inhibits tumor growth of mice by 75.97% relative to vehicle control . GSK-3β inhibitor 3 (15 mg/kg; a single i.p.) shows long T 1/2 of 14.2 h, high AUC values (AUC last =3503.42 ng/mL•h), and maximum concentration (C max =515 ng/mL) in mice . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Balb/c female nude mice were injected leukemia cells Dosage: 15 mg/kg/d Administration: I.p. for 2 weeks Result: Inhibited localized growth in NB4 cells. Had mild weight loss compared with control. Animal Model: Male ICR mice (30 g) Dosage: 15 mg/kg (Pharmacokinetic Analysis) Administration: A single i.p. Result: T 1/2 =14.2 h; AUC last =3503.42 ng/mL•h; C max =515 ng/mL.
IC50& Target:GSK-3β 6.6 μM (IC 50 )
规格
别名
GSK-3β 抑制剂 3
规格或纯度
10mM in DMSO
英文名称
GSK-3β inhibitor 3
生化机理
GSK-3β 抑制剂 3 是一种强效、选择性、不可逆的糖原合成酶激酶 3β （GSK-3β）共价抑制剂，IC50 为 6.6 μM。GSK-3β 抑制剂 3 可用于急性早幼粒细胞白血病的研究。
储存条件
-80℃储存
运输条件
特低温运输
作用类型
激活剂
名称和识别符
分子类型
小分子
分子量
327.37
技术文档
高级数据
质检证书(CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
溶液计算器
常见问题
本产品应如何储存？
请于?80 °C条件下保存。需超低温保存以维持规定的有效期。
本产品如何运输？
本产品采用干冰配冷袋冷冻运输。收货后请立即拆包，并按上述储存条件保存；处理干冰时请戴隔热手套并保持通风。
本产品的 CAS 号、分子式和分子量是多少？
本产品的 CAS 号为 1448990-73-5，分子式为 C18H14FNO2S，分子量为 327.37 g/mol。
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每个订单都会随附分析证书（COA），您也可以从账户订单历史中下载。如需订购前的COA，请联系您的客户代表，或使用PDP上的"申请COA"按钮——我们将提供代表性批次的COA。
产品仅提供给经过验证的企业、机构和合格的专业人员用于研发。不适用于人类、动物、诊断或治疗。
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