计算溶液所需的质量、体积或浓度。
为什么选择此级别
，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
-80℃储存。特低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
概述
Ginkgetin, a biflavone, is isolated from Ginkgo biloba leaves. Ginkgetin exhibit anti-tumor, anti-inflammatory, neuroprotective, anti-fungal activities. Ginkgetin is also a potent inhibitor of Wnt signaling , with an IC 50 of 5.92 μΜ.
In Vitro
Ginkgetin (2.5-20 μM; 48 h) inhibits the growth of Daoy and D283 cell lines, and induces G 2 /M cell cycle arrest in Daoy cells. Ginkgetin (20-40 μM; 24 h) significantly activates the apoptosis of osteosarcoma cells in a concentration-dependent manner. Ginkgetin (10-20 μM; 3-24 h) down-regulated the expression of Wnt target genes without affecting the expression of β-catenin in medulloblastoma cells. Ginkgetin (1-10 μM; 24 or 48 h) significantly inhibits the VEGF-induced endothelial cell proliferation, migration, and wound recovery in a concentration-dependent manner. Ginkgetin (5-10 μM; 48 h) induces autophagy responsible for cell death in A549 . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: Daoy and D283 cell lines Concentration: 2.5, 5, 10, 20 μM Incubation Time: 48 hours Result: Inhibited the cell growth, with IC 50 s of 14.65 and 15.81 μM for Daoy and D283 cells, respectively. Apoptosis AnalysisCell Line: Osteosarcoma cells Concentration: 20, 30, 40 μM Incubation Time: 24 hours Result: Markedly induced the apoptosis of osteosarcoma cells in a concentration-dependent manner. Cell Cycle AnalysisCell Line: Daoy cells Concentration: 2.5, 5, 10, 20 μM Incubation Time: 24 hours Result: Increased G 2 /M phase, compared with that of control, indicating a G 2 /M cell phase arrest. Cell Cycle AnalysisCell Line: Daoy and D283 cell lines Concentration: 10, 20 μM Incubation Time: 3, 6, 12, 24 hours Result: Attenuated the expression of Wnt target genes, Axin2, cyclin D1 and survivin at 20 μM for 24 h in Daoy cells. Unaffected the level of total β-catenin and diminished the level of β-catenin phosphorylation in a time- and concentration-dependent manner.
In Vivo
Ginkgetin (25-100 mg/kg; i.p. 2 hours after the onset of ischemia) exerts anti-inflammatory effects on cerebral ischemia/reperfusion-induced injury in a rat model via the TLR4/NF-κB signaling pathway. Ginkgetin (30 mg/kg; intragastrically once per day for 42 d) suppresses tumor growth in A549 cells bearing nude mice. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male Sprague-Dawley rats (200-220 g)Dosage: 25, 50, 100 mg/kg Administration: I.p. 2 hours after the onset of ischemia Result: Reduced the neurological deficit score. Suppressed the expression of NF-κB, TLR4 and IκBαin ischemic penumbra cortex, and inhibited the degradation of IκBα. Decreased the expressions of ICAM-1, COX-2, and iNOS. Downregulated downstream inflammatory factor PGE2 and TNF-α expression. Decreased IL-1β, IL-6, IL-8, and IL-10 protein expression.
规格
别名
银杏黄素
规格或纯度
10mM in DMSO
英文名称
Ginkgetin
生化机理
银杏黄酮是从银杏叶中分离出来的一种双黄酮。银杏黄酮具有抗肿瘤、抗炎、保护神经和抗真菌的活性。银杏黄酮还是一种有效的 Wnt 信号转导抑制剂，IC50 为 5.92 μΜ。
储存条件
-80℃储存
运输条件
特低温运输
名称和识别符
技术文档
高级数据
安全和危险性（GHS）
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
溶液计算器
常见问题
本产品应如何储存？
请于?80 °C条件下保存。需超低温保存以维持规定的有效期。
本产品如何运输？
本产品采用干冰配冷袋冷冻运输。收货后请立即拆包，并按上述储存条件保存；处理干冰时请戴隔热手套并保持通风。
本产品的 CAS 号、分子式和分子量是多少？
本产品的 CAS 号为 481-46-9，分子式为 C32H22O10，分子量为 566.51 g/mol。
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