计算溶液所需的质量、体积或浓度。
| 活性类型 | 活性值-log(M) | 作用机制 | 期刊 | 参考文献(PubMed IDs) |
|---|
为什么选择此级别
，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
-80℃储存。特低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
概述
GSK2983559 active metabolite is an active metabolite of GSK2983559. GSK2983559 active metabolite is a receptor interacting protein-2 ( RIP2 ) kinase inhibitor extracted from patent WO/2014043446 A1, compound example 1.
In Vitro
GSK2983559 active metabolite is a novel prodrug of a quinazolyl amine that inhibits RIP2 kinase. Receptor interacting protein-2 (RIP2) kinase, which is also referred to as CARD3, RICK, CARDIAK, or RIPK2, is a TKL family serine/threonine protein kinase involved in innate immune signaling. RIP2 kinase is composed of an N-terminal kinase domain and a C-terminal caspase-recruitment domain (CARD) linked via an intermediate (IM) region. The CARD domain of RIP2 kinase mediates interaction with other CARD-containing proteins, such as NODI and NOD2. NODI and NOD2 are cytoplasmic receptors which play a key role in innate immune surveillance. They recognize both gram positive and gram negative bacterial pathogens and are activated by specific peptidoglycan motifs, diaminopimelic acid (i.e., DAP) and muramyl dipeptide. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
IC50& Target:RIP2 Kinase
规格
别名
GSK2983559 活性代谢物
规格或纯度
10mM in DMSO
英文名称
GSK2983559 active metabolite
生化机理
GSK2983559 活性代谢物是 GSK2983559 的活性代谢物。GSK2983559 活性代谢物是一种受体互作蛋白-2 ( RIP2 ) 激酶抑制剂，提取自专利 WO/2014043446 A1，化合物示例 1。
储存条件
-80℃储存
运输条件
特低温运输
作用类型
抑制剂
名称和识别符
分子类型
未知
Isomeric SMILES
CC(C)(C)S(=O)(=O)C1=C(C=C2C(=C1)C(=NC=N2)NC3=CC4=C(C=C3)SC=N4)OCCO
PubChem CID
分子量
458.55
技术文档
高级数据
关联靶点（人）
RIPK2
Tchem
受体相互作用丝氨酸/苏氨酸蛋白激酶 2(Receptor-interacting serine/threonine-protein kinase 2)
(3 活性数据)
NOD2
Tclin
含核苷酸结合寡聚化结构域的蛋白2(Nucleotide-binding oligomerization domain-containing protein 2)
(2 活性数据)
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
溶液计算器
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