Human β-defensin-2 (HβD-2) is a small cysteine-rich cationic skin-antimicrobial peptide (SAP) produced by a number of epithelial cells.Human β-defensin-2 has antimicrobial activity against gram-negative bacteria and Candida , but not gram-positive Staphylococcus aureus. Human β-defensin-2 can be used for the study of colitis.