HDAC-IN-57 is an orally active inhibitor of histone deacetylases ( HDAC ), with IC 50 s of 2.07 nM, 4.71 nM, 2.4 nM and 107 nM for HDAC1 , HDAC2 , HDAC6 , HDAC8 , respectively. HDAC-IN-57 can inhibits LSD1, with IC 50 of 1.34 μΜ.HDAC-IN-57 induces apoptosis , and has anti-tumor activity.