计算溶液所需的质量、体积或浓度。
概述
H3R antagonist 4 (compound 11L) was a dual inhibitor of cholinesterase and histamine receptor ( H3R ), with corresponding IC 50 of 7.04 μM ( ee AChE ), 9.73 μM ( hAChE )(reversible) and 1.09 nM ( H3R ) , respectively. H3R antagonist 4 inhibited the aggregation of Aβ 1-42 induced by itself and Cu 2+ (95.48% and 88.63%) , and degraded the Aβ 1-42 fibrils induced by itself and Cu 2+ (80.16% and 89.30%).H3R antagonist 4 chelate biometals such as Cu 2+ , Zn 2+ , Al 3+ , and Fe 2+. H3R antagonist 4 significantly reduced tau protein hyperphosphorylation induced by Aβ 1-42 and inhibited RSL-3-induced apoptosis and ferroptosis in PC12 cells. H3R antagonist 4 had the best blood-brain barrier permeability and intestinal absorption in hCMEC/D3 and hPepT1-MDCK cells.H3R antagonist 4 ameliorates learning and memory impairment in a mouse model of Alzheimer's disease induced by scopolamine.
规格
英文名称
H3R antagonist 4
储存条件
室温
作用类型
抑制剂
名称和识别符
分子类型
小分子
高级数据
质检证书(CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
溶液计算器
产品仅提供给经过验证的企业、机构和合格的专业人员用于研发。不适用于人类、动物、诊断或治疗。
Copyright © 2023至今 上海阿拉丁生化科技股份有限公司 SSE:688179 保留所有权利。
危险品化学品经营许可证（带存储）