计算溶液所需的质量、体积或浓度。
HDM-IN-1 (Compound A4) is an inhibitor for fungal histone demethylase ( HDM ), that inhibits the H3K27me3 in Cryptococcus neoformans and in Candida auris with IC 50 s of 134 and 12 nM. HDM-IN-1 exhibits inhibitory efficacy against C. neoformans and C. auris with MIC 80 of 0.5-2 μg/mL, through inhibition of the biofilm and capsule formation. HDM-IN-1 exhibits antifungal activity in ICR mouse model.