HIV-1 inhibitor-79 (Compound 3k) is an HIV inhibitor that exhibits significant inhibitory activity against HIV-1 and its common mutant strains (with IC 50 values of 1.9, 1.9, 8.7, and 11 nM against HIV-1 , K103 , L100I , and E138K , respectively), and has low cytotoxicity and a high selectivity index ( CC 50 = 21.95 μM, SI = 11478). Additionally, HIV-1 inhibitor-79 also shows antiviral activity against HIV-2 , with an EC 50 value of 6.14 μM, and significantly inhibits the activity of HIV-1 reverse transcriptase ( IC 50 = 25 nM).