HIV-1 inhibitor-58 (Compound 10c) is a broad-spectrum antiviral agent. HIV-1 inhibitor-58 is a non-nucleoside reverse transcriptase inhibitor. HIV-1 inhibitor-58 inhibits WT strain IIIB, NNRTI-resistant strains (such as K103N and E138K) in MT-4 cells, with EC 50 less than 50 nM. HIV-1 inhibitor-58 also inhibits CYP2C9 and CYP2C19 ( IC 50 : 2.06 μM, 1.91 μM). HIV-1 inhibitor-58 can be used for HIV infection reserch.