HDAC-IN-83 (compound 9D) is an inhibitor of deacetylases (HDACs) ( IC 50 =0.01 μM/0.44 μM HDAC1/HDAC6) with anticancer , antiproliferative and caspase 3/7 activation activities. HDAC-IN-83 inhibits Cal27, HepG2 and MRC-5 with IC 50 s of 0.693 μM, 0.427 μM and 3.19 μM, respectively.