5-HT 1A R agonist 2 (Compound 4f) is a 5-HT 1A receptor agonist ( K i : 10.0 nM). 5-HT 1A R agonist 2 also binds to the SERT , D 2 receptor and 5-HT 6 receptor ( K i : SERT, 2.8 nM; D 2 , 23 nM; 5-HT 6 , 192 nM). 5-HT 1A R agonist 2 is stabilized in microsomes and induces hypothermia in mice.