5-HT2CR agonist 1 (compound 8), a 7-chloro analogue, is a selective 5-HT 2C R partial agonist (E max =71.09%) with an EC 50 value of 121.5 nM and no observed activity toward 5-HT 2A R or 5-HT 2B R. 5-HT2CR agonist 1 exhibits no recruitment activity for β-arrestin and shows low inhibition of hERG at 10 μM.