HuR degrader 2 (Compound 3) is a molecule glue, which targets RNA-binding protein Hu antigen R ( HuR ) and degrades 30% HuR at 0.1 μM. HuR degrader 2 inhibits the proliferation of cancer cell Colo-205, with IC 50 ≤200 nM. HuR degrader 2 exhibits a high affinity with cereblon , with an HTRF ratio < 0.02.