hNTS1R agonist-1 (Compound 10) is a BBB permeable hNTS1R full agonist ( K i : 6.9 nM). hNTS1R agonist-1 increases motor function and memory in a mouse model of Parkinson's disease (PD). hNTS1R agonist-1 is a Neurotensin(8-13) analog and is a neuroprotective agent.