hCAII-IN-10 (compound 11d) is hCA II inhibitor with the IC 50 s of 14 nM and 29.2 μM for hCA II and hCA I , respectively. hCAII-IN-10 inhibits cell growth against HT-29 cells with the IC 50 of 74 μM. hCAII-IN-10 shows strongly lowered intraocular pressure in the glaucomatous rabbit eye model.