7-Hydroxyneolamellarin A is a natural product that could be derived from sponge Dendrilla nigra. 7-Hydroxyneolamellarin A is a potent hypoxia-inducible factor-1α ( HIF-1α ) inhibitor. 7-Hydroxyneolamellarin A attenuates the accumulation of hypoxia-inducible factor-1α ( HIF-1α ) protein and inhibits vascular epidermal growth factor ( VEGF ) transcriptional activity. 7-Hydroxyneolamellarin A can be used in research of cancer.