hCA/VEGFR-2-IN-1 (compound 13a) is a potent dual Carbonic Anhydrase( CA ) IX/XII with K i values of 4.7 nM and 8.3 nM for hCA XII and hCA IX, respectively. hCA/VEGFR-2-IN-1 (compound 13a) is a potent VEGFR-2 inhibitor with IC 50 values 26.3 nM. hCA/VEGFR-2-IN-1 has anticancer activity.