hAChE-IN-9 (compound 7i) is a selective inhibitor of human acetylcholinesterase ( hAChE ) with IC 50 of 0.05 μM and 2.85 μM for AChE and BChE , respectively. hAChE-IN-9 modulates toxic Aβ oligomer forms into non-toxic ones and has antioxidant and neuroprotective effects against Aβ -induced toxicity. hAChE-IN-9 can be used for the study of Alzheimer's disease.