hAChE-IN-10 (Compound ET11) is the inhibitor for human acetylcholinesterase ( AChE ) with an IC 50 of 6.34 nM. hAChE-IN-10 scavenges free radicals, and exhibits antioxidant activity. hAChE-IN-10 exhibits metal chelating activity, inhibits Cu 2+ -induced Aβ1-42 aggregation, reduces the formation of amyloid plaques, and exhibits neuroprotective activity. hAChE-IN-10 ameliorates the Scopolamine -induced cognitive impairment in mouse models.