hAChE-IN-8 (Compound S-12) is a orally effective and selective inhibitor of hAChE ( IC 50 =0.486 μM). hAChE-IN-8 also inhibits BACE-1 ( IC 50 =0.542 μM), and does not inhibit Dyrk1A ( IC 50 >10 μM). hAChE-IN-8 can reduce Aβ aggregation, has good blood-brain barrier penetration. hAChE-IN-8 is mainly used in Alzheimer's disease research.