| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| H408276-1ml |
1ml |
现货  |
|
| 英文别名 | Afimoxifene | Phenol, 4-[1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]- |
|---|---|
| 规格或纯度 | 10mM in DMSO |
| 英文名称 | 4-Hydroxytamoxifen (Afimoxifene) |
| 生化机理 | 4-羟基他莫昔芬（阿非莫昔芬）是他莫昔芬的活性代谢产物，也是一种选择性雌激素受体（ER）调节剂，被广泛用于乳腺癌的治疗和化学预防。它能激活 intein-Cas9 变体的靶向修饰频率。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 产品介绍 |
4-Hydroxytamoxifen是tamoxifen的活性代谢产物，是一种选择性的雌激素受体调节分子，在乳腺癌的治疗和化学疗法中应用广泛化疗药物它莫西芬的代谢产物,抑制许多潜在雌激素的活性,也能激活如膜间脂质过氧化反应的抑制剂。 Information 4-Hydroxytamoxifen (Afimoxifene) 4-Hydroxytamoxifen (Afimoxifene) is the active metabolite of tamoxifen and a selective estrogen receptor (ER) modulator that is widely used in the therapeutic and chemopreventive treatment of breast cancer. It activates 4-OHT is a potent activator of ER and has been shown to have a higher affinity for estrogen receptors compared to tamoxifen. It has significant dose and time-dependent direct effects to alter the contractile function of isolated adult rat cardiac myocytes. 4-HT activates on-target modification frequency for intein-Cas9 variants . In vivo
cell lines： Concentrations：0, 0.5, 1, 3, 5, and 10 µM Incubation Time：15-45 min Powder Purity:≥98% |
| ALogP | 6.077 |
|---|---|
| hba_count | 1 |
| HBD Count | 1 |
| Rotatable Bond | 8 |
| 分子类型 | 小分子 |
|---|---|
| Canonical SMILES | CCC(C1=CC=CC=C1)=C(C2=CC=C(O)C=C2)C3=CC=C(OCCN(C)C)C=C3 |
| 分子量 | 387.51 |
| Reaxy-Rn | 7941290 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=7941290&ln= |
| DMSO(mg / mL) Max Solubility | 77 |
|---|---|
| DMSO(mM) Max Solubility | 198.7 |
| Water(mg / mL) Max Solubility | <1 |
| Reaxy-Rn | 7941290 |
|---|---|
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=7941290&ln= |
| Concentration | 9-11（mmol/L） |
|---|---|
| Proton NMR spectrum | Conforms to Structure |
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