HDAC10-IN-1 (compound 13b) is a potent and highly selective HDAC10 inhibitor, with an IC 50 of 58 nM. HDAC10-IN-1 modulates autophagy in aggressive FLT3-ITD positive acute myeloid leukemia cells.
Biological Activity:HDAC10-IN-1 (compound 13b) is a potent and highly selective HDAC10 inhibitor, with an IC 50 of 58 nM. HDAC10-IN-1 modulates autophagy in aggressive FLT3-ITD positive acute myeloid leukemia cells.