IHMT-TRK-284 (Compound 34) is a potent, orally active type II TRK kinase inhibitor with IC 50 values of 10.5, 0.7, and 2.6 nM to TRKA , B , and C respectively. IHMT-TRK-284 displays great selectivity profile in the kinome and good in vivo antitumor efficacies.