ICMT-IN-35 (compound 10n) is a FTPA-triazole compound and ICMT inhibitor ( IC 50 =0.8 μM). ICMT-IN-35 is taken up by mammalian cells and can prevent K-Ras membrane localization and induce K-Ras mislocalization. Furthermore, ICMT -IN-35 is selectively cytotoxic against ICMT +/+ MEF cells and has low micromolar activity ( IC 50 =0.8 μM) against metastatic pancreatic cancer cell lines.