首页   400-620-6333
为了更好地浏览阿拉丁的产品，请在使用“QQ浏览器”或“360浏览器”时切换到极速模式。查看明细
  • 登录
  • 注册
  • 英文站
切换导航
我的购物车
搜索
搜索444
高级搜索
菜单
登录
྾

3-异丁基-1-甲基黄嘌呤(IBMX), A 1 受体拮抗剂

非特异性cAMP和cGMP抑制剂
22篇引用文献
有货

库存信息

关闭
货号 (SKU) 包装规格 是否现货 价格 数量
I423008-1ml
 1ml 现货 Stock Image
大包装询价 添加到收藏夹 比较  SDS中文版  DATASHEET
查看相关系列
Compound libraries (12316) Nucleosides (90)
main product photo

基本描述

别名 IBMX | 1-甲基-3-异丁基黄嘌呤
英文别名 IBMX | 3-Isobutyl-1-methylxanthine | 28822-58-4 | isobutylmethylxanthine | Methylisobutylxanthine | 1-METHYL-3-ISOBUTYLXANTHINE | 1H-Purine-2,6-dione, 3,7-dihydro-1-methyl-3-(2-methylpropyl)- | 3-Isobutyl-1-methyl-1H-purine-2,6(3H,7H)-dione | 3-isobutyl-1-methylxanthine
规格或纯度 Moligand™, 10mM in DMSO
英文名称 3-Isobutyl-1-methylxanthine
生化机理 非特异性cAMP和cGMP抑制剂
储存温度 -80℃储存
运输条件 超低温冰袋运输
作用类型 拮抗剂
作用机制 A 1 受体拮抗剂
产品介绍

IBMX is a widely-used non-specific inhibitor of cyclic AMP (cAMP) and cyclic GMP (cGMP) phosphodiesterases (PDEs) (IC50 = 19, 50, 18, 13, 32, 7, and 50 μM for PDE1, PDE2, PDE3, PDE4, PDE5, PDE7, and PDE11, respectively). PDE8A, PDE8B, and PDE9 are insensitive to IBMX. By inhibiting PDEs, IBMX increases cellular cAMP and cGMP levels, activating cyclic-nucleotide-regulated protein kinases. Methylxanthines, including IBMX, caffeine, and theophylline, bind adenosine receptors,typically antagonizing the suppressive effects of natural agonists.

IBMX is a widely-used non-specific inhibitor of cyclic AMP (cAMP) and cyclic GMP (cGMP) phosphodiesterases (PDEs) (IC50 = 19, 50, 18, 13, 32, 7, and 50 μM for PDE1, PDE2, PDE3, PDE4, PDE5, PDE7, and PDE11, respectively). PDE8A, PDE8B, and PDE9 are insensitive to IBMX. By inhibiting PDEs, IBMX increases cellular cAMP and cGMP levels, activating cyclic-nucleotide-regulated protein kinases. Methylxanthines, including IBMX, caffeine, and theophylline, bind adenosine receptors,typically antagonizing the suppressive effects of natural agonists.
Non-specific inhibitor of cAMP and cGMP phosphodiesterases. The increase in cAMP level as a result of phosphodiesterase inhibition by IBMX activates PKA leading to decreased proliferation, increased differentiation, and induction of apoptosis. IBMX inhibits phenylephrine-induced release of 5-hydroxytryptamine from neuroendocrine epithelial cells of the airway mucosa (IC50: 1.3 μM). Also serves as an adenosine receptor antagonist. Shown to inhibit ion channels in the neuromuscular junction, GH3 cells, and vascular smooth muscle cells. Induces calcium release from intracellular stores in sensory neurons.

AI解读

关联靶点（人）

PDE3B Tclin cGMP 抑制的 3',5'-环磷酸二酯酶 B(cGMP-inhibited 3',5'-cyclic phosphodiesterase B) (1 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
ADORA1 Tclin 腺苷受体A1(Adenosine receptor A1) (1 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
PDE5A Tclin Phosphodiesterase 5A (5113 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
TSHR Tclin Thyroid stimulating hormone receptor (29986 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ADORA1 Tclin Adenosine A1 receptor (17603 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CACNA1C Tclin Voltage-gated L-type calcium channel alpha-1C subunit (766 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PDE3A Tclin Phosphodiesterase 3A (3309 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ADORA2A Tclin Adenosine A2a receptor (16305 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PDE4B Tclin Phosphodiesterase 4B (2748 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP2D6 Tclin Cytochrome P450 2D6 (33882 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PDE3B Tclin Phosphodiesterase 3B (312 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GLP1R Tclin Glucagon-like peptide 1 receptor (111429 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PDE7A Tclin Phosphodiesterase 7A (1104 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP1A2 Tchem Cytochrome P450 1A2 (26471 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP2C9 Tchem Cytochrome P450 2C9 (32119 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP2C19 Tchem Cytochrome P450 2C19 (29246 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
CYP3A4 Tclin Cytochrome P450 3A4 (53859 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PDE9A Tchem Phosphodiesterase 9A (1131 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
HEK293 (82097 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Monocyte (474 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
KDM4A Tchem Lysine-specific demethylase 4A (52245 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Skin (286 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GMNN Tbio Geminin (128009 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (2672 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (2517 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SLC16A3 Tchem Monocarboxylate transporter 4 (196 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PDE4A Tclin Phosphodiesterase 4 (3344 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PDE1A Tclin Phosphodiesterase 1 (671 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PDE4A Tclin Phosphodiesterase; PDE3 & PDE4 (301 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PDE7A Tclin Phosphodiesterase 7 (77 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
ADORA1 Tclin Adenosine receptor (26 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

关联靶点（其它种属）

PDE2A Phosphodiesterase 2A (77 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Pde4d Phosphodiesterase 4D (4 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Mapk1 MAP kinase ERK2 (650 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Pde8a Phosphodiesterase 8A (1 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Canis familiaris (36305 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Rattus norvegicus (775804 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
3T3-L1 (3664 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
GCN5 Histone acetyltransferase GCN5 (89 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Adora2b Adenosine A2 receptor (1828 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
Scn2a Sodium channel alpha subunits; brain (Types I, II, III) (344 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PDE1B Heart phosphodiesterase (70 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
PDEB1 Class I phosphodiesterase PDEB1 (2 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID
SARS-CoV-2 (38078 活性数据)
活性类型 Relation Activity value Units Action Type Journal PubMed Id doi Assay Aladdin ID

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

名称和识别符

EC号 249-259-3
分子类型 小分子
IUPAC Name 1-methyl-3-(2-methylpropyl)-7H-purine-2,6-dione
INCHI InChI=1S/C10H14N4O2/c1-6(2)4-14-8-7(11-5-12-8)9(15)13(3)10(14)16/h5-6H,4H2,1-3H3,(H,11,12)
InChi Key APIXJSLKIYYUKG-UHFFFAOYSA-N
Canonical SMILES CC(C)CN1C2=C(C(=O)N(C1=O)C)NC=N2
Isomeric SMILES CC(C)CN1C2=C(C(=O)N(C1=O)C)NC=N2
WGK Germany 3
RTECS ZD8500000
PubChem CID 3758
分子量 222.24
Beilstein号 247859

化学和物理性质

熔点 200-203°C
分子量 222.240 g/mol
XLogP3 1.500
氢键供体数Hydrogen Bond Donor Count 1
氢键受体数Hydrogen Bond Acceptor Count 3
可旋转键计数Rotatable Bond Count 2
精确质量Exact Mass 222.112 Da
单同位素质量Monoisotopic Mass 222.112 Da
拓扑极表面积Topological Polar Surface Area 69.300 Ų
重原子数Heavy Atom Count 16
形式电荷Formal Charge 0
复杂度Complexity 318.000
同位素原子数Isotope Atom Count 0
定义的原子立体中心计数Defined Atom Stereocenter Count 0
未定义的原子立体中心计数Undefined Atom Stereocenter Count 0
定义的键立体中心计数Defined Bond Stereocenter Count 0
未定义的键立体中心计数Undefined Bond Stereocenter Count 0
所有立体化学键的总数The total count of all stereochemical bonds 0
共价键合单元计数Covalently-Bonded Unit Count 1

安全和危险性（GHS）

象形图 GHS07
信号词 Warning
危险声明

H302: 吞食有害
预防措施声明

P501: 将内容物/容器处理到。。。

P264: 处理后要彻底洗手。

P270: 使用本产品时，请勿进食、饮水或吸烟。

P330: 漱口

P301+P317: 如果被吞咽：请寻求医疗帮助。
WGK Germany 3
RTECS ZD8500000
个人防护装备 dust mask type N95 (US),Eyeshields,Faceshields,Gloves

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:

此产品的引用文献

如何在您的发表作品中引用阿拉丁的产品和网站?
1. Ling Yang, Linzi Li, Qian Lu, Lingfeng Li, Chun Xie, Fakun Jiang, Hongbing Li, Ai Zhao, Qian Wang, Wenyong Xiong.  (2023)  Alisol B blocks the development of HFD-induced obesity by triggering the LKB1-AMPK signaling in subcutaneous adipose tissue.  EUROPEAN JOURNAL OF PHARMACOLOGY,  956  (175942).  [PMID:37536624] [10.1016/j.ejphar.2023.175942]
2. Gui-Bo Liu, Yong-Xia Cheng, Hua-Min Li, Yong Liu, Li-Xin Sun, Qi Wu, Shang-Fu Guo, Ting-Ting Li, Chuan-Ling Dong, Ge Sun.  (2023)  Ghrelin promotes cardiomyocyte differentiation of adipose tissue‑derived mesenchymal stem cells by DDX17‑mediated regulation of the SFRP4/Wnt/β‑catenin axis.  Molecular Medicine Reports,  28  (3): (1-14).  [PMID:37449526] [10.3892/mmr.2023.13050]
3. Xinyan Tao, Yuan Liu, Zhenhua Ding, Shuang Xie, Wenxiong Cao, Xiaohong Li.  (2023)  Injectable cell-targeting fiber rods to promote lipolysis and regulate inflammation for obesity treatment.  Biomaterials Science,  [PMID:37432672] [10.1039/D3BM00619K]
4. Yawei Kong, Jianpeng Ao, Qiushu Chen, Wenhua Su, Yinping Zhao, Yiyan Fei, Jiong Ma, Minbiao Ji, Lan Mi.  (2023)  Evaluating Differentiation Status of Mesenchymal Stem Cells by Label-Free Microscopy System and Machine Learning.  Cells,  12  (11): (1524).  [PMID:37296645] [10.3390/cells12111524]
5. Gao Rongyin, Zhang Ximei, Zou Kun, Meng Duo, Lv Jinpeng.  (2023)  Cryptochrome 1 activation inhibits melanogenesis and melanosome transport through negative regulation of cAMP/PKA/CREB signaling pathway.  Frontiers in Pharmacology,  14  [PMID:36814484] [10.3389/fphar.2023.1081030]
6. Xiaoxue Ren, Xiaoting Gao, Yicheng Cheng, Lingxia Xie, Liping Tong, Wei Li, Paul K. Chu, Huaiyu Wang.  (2022)  Maintenance of multipotency of bone marrow mesenchymal stem cells on poly(ε-caprolactone) nanoneedle arrays through the enhancement of cell-cell interaction.  Frontiers in Bioengineering and Biotechnology,  10  (1076345).  [PMID:36698633] [10.3389/fbioe.2022.1076345]
7. Fei He, Chendong Yang, Haoye Liu, Jizeng Wang.  (2023)  Changes in the mechanical properties of human mesenchymal stem cells during differentiation.  Royal Society Open Science,  10  (1): [PMID:36636310] [10.1098/rsos.220607]
8. Xiaoyu Cai, Songxue Wang, Huali Wang, Suwen Liu, Guishan Liu, Huibin Chen, Ji Kang, Hao Wang.  (2023)  Naringenin inhibits lipid accumulation by activating the AMPK pathway in vivo and vitro.  Food Science and Human Wellness,  12  (1174).  [10.1016/j.fshw.2022.10.043]
9. Shuai Chen, Yicheng Jiang, Xiaoyang Qi, Peng Song, Liming Tang, Hanyang Liu.  (2022)  Bioinformatics analysis to obtain critical genes regulated in subcutaneous adipose tissue after bariatric surgery.  Adipocyte,  11  (1): (550-561).  [PMID:36036283] [10.1080/21623945.2022.2115212]
10. Zhu Shenglong, Zhang Jingwei, Wang Wei, Jiang Xuan, Chen Yong Q..  (2022)  Blockage of NDUFB9-SCD1 pathway inhibits adipogenesis.  JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY,  78  (2): (377-388).  [PMID:35122619] [10.1007/s13105-022-00876-7]
11. Zhu Shenglong, Wang Wei, Zhang Jingwei, Ji Siyu, Jing Zhe, Chen Yong Q..  (2022)  Slc25a5 regulates adipogenesis by modulating ERK signaling in OP9 cells.  CELLULAR & MOLECULAR BIOLOGY LETTERS,  27  (1): (1-13).  [PMID:35109789] [10.1186/s11658-022-00314-y]
12. Jing Zhou, Ji Zhang, Jiayi Li, Yiqiu Guan, Ting Shen, Fu Li, Xueqin Li, Xiaojun Yang, Weicheng Hu.  (2021)  Ginsenoside F2 Suppresses Adipogenesis in 3T3-L1 Cells and Obesity in Mice via the AMPK Pathway.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,  69  (32): (9299–9312).  [PMID:34342980] [10.1021/acs.jafc.1c03420]
13. Lou Hai-xia, Fu Wen-cheng, Chen Jia-xiang, Li Tian-tian, Jiang Ying-ying, Liu Chun-hui, Zhang Wen.  (2021)  Alisol A 24-acetate stimulates lipolysis in 3 T3-L1 adipocytes.  BMC Complementary Medicine and Therapies,  21  (1): (1-11).  [PMID:33888116] [10.1186/s12906-021-03296-0]
14. Zhenhua Ding, Maohua Chen, Xinyan Tao, Yuan Liu, Jie He, Tao Wang, Xiaohong Li.  (2021)  Synergistic Treatment of Obesity via Locally Promoting Beige Adipogenesis and Antioxidative Defense in Adipose Tissues.  ACS Biomaterials Science & Engineering,  7  (2): (727–738).  [PMID:33397089] [10.1021/acsbiomaterials.0c01181]
15. Suwen Liu, Xuedong Chang, Jincheng Yu, Weifeng Xu.  (2020)  Cerasus humilis Cherry Polyphenol Reduces High-Fat Diet-Induced Obesity in C57BL/6 Mice by Mitigating Fat Deposition, Inflammation, and Oxidation.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,  68  (15): (4424–4436).  [PMID:32227855] [10.1021/acs.jafc.0c01617]
16. Minchi Liu, Wenjun Qian, Selvaraj Subramaniyam, Shuang Liu, Wenkuan Xin.  (2020)  Denatonium enhanced the tone of denuded rat aorta via bitter taste receptor and phosphodiesterase activation.  EUROPEAN JOURNAL OF PHARMACOLOGY,  872  (172951).  [PMID:32006560] [10.1016/j.ejphar.2020.172951]
17. Fiorency Santoso, Bonifasius Putera Sampurna, Yu-Heng Lai, Sung-Tzu Liang, Erwei Hao, Jung-Ren Chen, Chung-Der Hsiao.  (2019)  Development of a Simple ImageJ-Based Method for Dynamic Blood Flow Tracking in Zebrafish Embryos and Its Application in Drug Toxicity Evaluation.  Inventions,  4  (4): (65).  [10.3390/inventions4040065]
18. Kun Feng, Chen Li, Yun-Shan Wei, Min-Hua Zong, Hong Wu, Shuang-Yan Han.  (2019)  Development of a polysaccharide based multi-unit nanofiber mat for colon-targeted sustained release of salmon calcitonin.  JOURNAL OF COLLOID AND INTERFACE SCIENCE,  552  (186).  [PMID:31125829] [10.1016/j.jcis.2019.05.037]
19. Kaimin Wu, Ruiyi Zhang, Yanhui Lu, Lulu Wen, Yanfei Li, Ranran Duan, Yaobing Yao, Yanjie Jia.  (2019)  Lin28B regulates the fate of grafted mesenchymal stem cells and enhances their protective effects against Alzheimer's disease by upregulating IGF-2.  JOURNAL OF CELLULAR PHYSIOLOGY,  234  (12): (21860-21876).  [PMID:31066045] [10.1002/jcp.28750]
20. Zhang Kaina, Zeng Ke, Shen Congcong, Tian Shiyu, Yang Minghui.  (2018)  Determination of protein kinase A activity and inhibition by using hydroxyapatite nanoparticles as a fluorescent probe.  MICROCHIMICA ACTA,  185  (4): (1-7).  [PMID:29594552] [10.1007/s00604-018-2754-1]
21. Qian Wang, Shuang-ting Wang, Xin Yang, Pan-pan You, Wen Zhang.  (2015)  Myricetin suppresses differentiation of 3 T3-L1 preadipocytes and enhances lipolysis in adipocytes.  NUTRITION RESEARCH,  35  (317).  [PMID:25724338] [10.1016/j.nutres.2014.12.009]
22. Luo M et al..  (2020)  Sanguinarine Rapidly Relaxes Rat Airway Smooth Muscle Cells Dependent on TAS2R Signaling..  Biol Pharm Bull,  43  (7): (1027-1034).  [PMID:32404582]

参考文献

1. Ling Yang, Linzi Li, Qian Lu, Lingfeng Li, Chun Xie, Fakun Jiang, Hongbing Li, Ai Zhao, Qian Wang, Wenyong Xiong.  (2023)  Alisol B blocks the development of HFD-induced obesity by triggering the LKB1-AMPK signaling in subcutaneous adipose tissue.  EUROPEAN JOURNAL OF PHARMACOLOGY,  956  (175942).  [PMID:37536624] [10.1016/j.ejphar.2023.175942]
2. Gui-Bo Liu, Yong-Xia Cheng, Hua-Min Li, Yong Liu, Li-Xin Sun, Qi Wu, Shang-Fu Guo, Ting-Ting Li, Chuan-Ling Dong, Ge Sun.  (2023)  Ghrelin promotes cardiomyocyte differentiation of adipose tissue‑derived mesenchymal stem cells by DDX17‑mediated regulation of the SFRP4/Wnt/β‑catenin axis.  Molecular Medicine Reports,  28  (3): (1-14).  [PMID:37449526] [10.3892/mmr.2023.13050]
3. Xinyan Tao, Yuan Liu, Zhenhua Ding, Shuang Xie, Wenxiong Cao, Xiaohong Li.  (2023)  Injectable cell-targeting fiber rods to promote lipolysis and regulate inflammation for obesity treatment.  Biomaterials Science,  [PMID:37432672] [10.1039/D3BM00619K]
4. Yawei Kong, Jianpeng Ao, Qiushu Chen, Wenhua Su, Yinping Zhao, Yiyan Fei, Jiong Ma, Minbiao Ji, Lan Mi.  (2023)  Evaluating Differentiation Status of Mesenchymal Stem Cells by Label-Free Microscopy System and Machine Learning.  Cells,  12  (11): (1524).  [PMID:37296645] [10.3390/cells12111524]
5. Gao Rongyin, Zhang Ximei, Zou Kun, Meng Duo, Lv Jinpeng.  (2023)  Cryptochrome 1 activation inhibits melanogenesis and melanosome transport through negative regulation of cAMP/PKA/CREB signaling pathway.  Frontiers in Pharmacology,  14  [PMID:36814484] [10.3389/fphar.2023.1081030]
6. Xiaoxue Ren, Xiaoting Gao, Yicheng Cheng, Lingxia Xie, Liping Tong, Wei Li, Paul K. Chu, Huaiyu Wang.  (2022)  Maintenance of multipotency of bone marrow mesenchymal stem cells on poly(ε-caprolactone) nanoneedle arrays through the enhancement of cell-cell interaction.  Frontiers in Bioengineering and Biotechnology,  10  (1076345).  [PMID:36698633] [10.3389/fbioe.2022.1076345]
7. Fei He, Chendong Yang, Haoye Liu, Jizeng Wang.  (2023)  Changes in the mechanical properties of human mesenchymal stem cells during differentiation.  Royal Society Open Science,  10  (1): [PMID:36636310] [10.1098/rsos.220607]
8. Xiaoyu Cai, Songxue Wang, Huali Wang, Suwen Liu, Guishan Liu, Huibin Chen, Ji Kang, Hao Wang.  (2023)  Naringenin inhibits lipid accumulation by activating the AMPK pathway in vivo and vitro.  Food Science and Human Wellness,  12  (1174).  [10.1016/j.fshw.2022.10.043]
9. Shuai Chen, Yicheng Jiang, Xiaoyang Qi, Peng Song, Liming Tang, Hanyang Liu.  (2022)  Bioinformatics analysis to obtain critical genes regulated in subcutaneous adipose tissue after bariatric surgery.  Adipocyte,  11  (1): (550-561).  [PMID:36036283] [10.1080/21623945.2022.2115212]
10. Zhu Shenglong, Zhang Jingwei, Wang Wei, Jiang Xuan, Chen Yong Q..  (2022)  Blockage of NDUFB9-SCD1 pathway inhibits adipogenesis.  JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY,  78  (2): (377-388).  [PMID:35122619] [10.1007/s13105-022-00876-7]
11. Zhu Shenglong, Wang Wei, Zhang Jingwei, Ji Siyu, Jing Zhe, Chen Yong Q..  (2022)  Slc25a5 regulates adipogenesis by modulating ERK signaling in OP9 cells.  CELLULAR & MOLECULAR BIOLOGY LETTERS,  27  (1): (1-13).  [PMID:35109789] [10.1186/s11658-022-00314-y]
12. Jing Zhou, Ji Zhang, Jiayi Li, Yiqiu Guan, Ting Shen, Fu Li, Xueqin Li, Xiaojun Yang, Weicheng Hu.  (2021)  Ginsenoside F2 Suppresses Adipogenesis in 3T3-L1 Cells and Obesity in Mice via the AMPK Pathway.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,  69  (32): (9299–9312).  [PMID:34342980] [10.1021/acs.jafc.1c03420]
13. Lou Hai-xia, Fu Wen-cheng, Chen Jia-xiang, Li Tian-tian, Jiang Ying-ying, Liu Chun-hui, Zhang Wen.  (2021)  Alisol A 24-acetate stimulates lipolysis in 3 T3-L1 adipocytes.  BMC Complementary Medicine and Therapies,  21  (1): (1-11).  [PMID:33888116] [10.1186/s12906-021-03296-0]
14. Zhenhua Ding, Maohua Chen, Xinyan Tao, Yuan Liu, Jie He, Tao Wang, Xiaohong Li.  (2021)  Synergistic Treatment of Obesity via Locally Promoting Beige Adipogenesis and Antioxidative Defense in Adipose Tissues.  ACS Biomaterials Science & Engineering,  7  (2): (727–738).  [PMID:33397089] [10.1021/acsbiomaterials.0c01181]
15. Suwen Liu, Xuedong Chang, Jincheng Yu, Weifeng Xu.  (2020)  Cerasus humilis Cherry Polyphenol Reduces High-Fat Diet-Induced Obesity in C57BL/6 Mice by Mitigating Fat Deposition, Inflammation, and Oxidation.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,  68  (15): (4424–4436).  [PMID:32227855] [10.1021/acs.jafc.0c01617]
16. Minchi Liu, Wenjun Qian, Selvaraj Subramaniyam, Shuang Liu, Wenkuan Xin.  (2020)  Denatonium enhanced the tone of denuded rat aorta via bitter taste receptor and phosphodiesterase activation.  EUROPEAN JOURNAL OF PHARMACOLOGY,  872  (172951).  [PMID:32006560] [10.1016/j.ejphar.2020.172951]
17. Fiorency Santoso, Bonifasius Putera Sampurna, Yu-Heng Lai, Sung-Tzu Liang, Erwei Hao, Jung-Ren Chen, Chung-Der Hsiao.  (2019)  Development of a Simple ImageJ-Based Method for Dynamic Blood Flow Tracking in Zebrafish Embryos and Its Application in Drug Toxicity Evaluation.  Inventions,  4  (4): (65).  [10.3390/inventions4040065]
18. Kun Feng, Chen Li, Yun-Shan Wei, Min-Hua Zong, Hong Wu, Shuang-Yan Han.  (2019)  Development of a polysaccharide based multi-unit nanofiber mat for colon-targeted sustained release of salmon calcitonin.  JOURNAL OF COLLOID AND INTERFACE SCIENCE,  552  (186).  [PMID:31125829] [10.1016/j.jcis.2019.05.037]
19. Kaimin Wu, Ruiyi Zhang, Yanhui Lu, Lulu Wen, Yanfei Li, Ranran Duan, Yaobing Yao, Yanjie Jia.  (2019)  Lin28B regulates the fate of grafted mesenchymal stem cells and enhances their protective effects against Alzheimer's disease by upregulating IGF-2.  JOURNAL OF CELLULAR PHYSIOLOGY,  234  (12): (21860-21876).  [PMID:31066045] [10.1002/jcp.28750]
20. Zhang Kaina, Zeng Ke, Shen Congcong, Tian Shiyu, Yang Minghui.  (2018)  Determination of protein kinase A activity and inhibition by using hydroxyapatite nanoparticles as a fluorescent probe.  MICROCHIMICA ACTA,  185  (4): (1-7).  [PMID:29594552] [10.1007/s00604-018-2754-1]
21. Qian Wang, Shuang-ting Wang, Xin Yang, Pan-pan You, Wen Zhang.  (2015)  Myricetin suppresses differentiation of 3 T3-L1 preadipocytes and enhances lipolysis in adipocytes.  NUTRITION RESEARCH,  35  (317).  [PMID:25724338] [10.1016/j.nutres.2014.12.009]
22. Luo M et al..  (2020)  Sanguinarine Rapidly Relaxes Rat Airway Smooth Muscle Cells Dependent on TAS2R Signaling..  Biol Pharm Bull,  43  (7): (1027-1034).  [PMID:32404582]

溶液计算器

上海阿拉丁生化科技股份有限公司
© 2016 ALADDIN-E.COM . 版权所有,未经授权禁止拷贝本站资料,如有违反,将追究法律责任

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用。

上海工商 危险品化学品经营许可证（带存储）营业执照(三证合一)