IDT307, an analog of the organic cation MPP+, is a specific fluorescent substrate for DAT (fluorescent substrate APP+).
In Vitro
IDT307, an analog of the organic cation MPP+, is transported into CP epithelial cells at the apical (CSF-facing) membrane and sensitive to inhibition by the PMAT inhibitor quinine. IDT307 uptake and intracellular accumulation is greatly attenuated by ~70% in CP tissue from the Pmat knockout mouse. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
规格
规格或纯度
10mM in DMSO
英文名称
IDT307
生化机理
IDT307 是有机阳离子 MPP+ 的类似物,是 DAT 的特异性荧光底物(荧光底物 APP+)。