计算溶液所需的质量、体积或浓度。
为什么选择此级别
，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
避光,干燥,-80℃储存。特低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
概述
IM156 (HL156A; HL271 acetate), a chemical derivative of Metformin , is a potent and orally active AMPK activator that increases AMPK phosphorylation. IM156 attenuates aging-associated cognitive impairment in animal model IM156 is a potent oxidative phosphorylation (OXPHOS) inhibitor which can be used for the research of solid tumors
In Vitro
IM156 (0.31-10 μM) phosphorylates AMPKα1 Thr172 in a dose- and time-dependent manner in NIH3T3 mouse fibroblast cells. IM156 does not affect the expression of key factors involved in glucose homeostasis such as glucose-6-phosphatase (G6pase) or phosphoenolpyruvate carboxykinase 1 (Pck1). MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: NIH3T3 cells Concentration: 0.31 μM, 0.62 μM, 1.25 μM, 2.5 μM, 5 μM, 10 μM Incubation Time: 4 hours Result: Significantly increased the AMPK phosphorylation rate.
In Vivo
IM156 does not affect metabolic regulation assessed by body weight, blood glucose, insulin levels and lipid metabolite content in mice with diet-induced obesity . IM156 (50 mg/kg; for 2 months) does not affect body weight, general locomotion, or anxiety. IM156 significantly attenuates the aging-induced decline in novel object recognition memory and spatial working memory. IM156 significantly increases AMPK activation in the hippocampus of aged mice. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: C57BL/6J mice (young group/12-16 weeks, old groups/20-22 months)Dosage: 50 mg/kg Administration: Oral administration (drinking water), for 2 months Result: Attenuated age-related cognitive decline.
IC50& Target:AMPK, OXPHOS
规格
规格或纯度
10mM in DMSO
英文名称
IM156
生化机理
IM156（HL156A；HL271 乙酸酯）是二甲双胍（HY-B0627）的一种化学衍生物，是一种强效的口服活性 AMPK 激活剂，可增加 AMPK 磷酸化。IM156 可减轻动物模型中与衰老相关的认知障碍。IM156
储存条件
避光,干燥,-80℃储存
运输条件
特低温运输
作用类型
激活剂
名称和识别符
分子类型
小分子
Isomeric SMILES
CC(=O)O.C1CCN(C1)/C(=N/C(=NC2=CC=C(C=C2)OC(F)(F)F)N)/N
PubChem CID
分子量
375.35
技术文档
高级数据
质检证书（CoA,COO,BSE/TSE 和分析图谱)
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溶液计算器
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