JAK-IN-38 (Compound 1) is a JAK inhibitor, with IC 50 s of0.03, 0.06, 0.12, 0.44 μM for Tyk2 , JAK3 , JAK2 , JAK1 respectively. JAK-IN-38 is a collagen VII ( C7 ) inducer and has anti-inflammatory activity. JAK-IN-38 can upregulate the expression of COL7A1 mRNA in donor-derived keratinocytes and works together with Gentamicin to boost overall C7 levels.