JNJ-39729209 is an antagonist for transient receptor potential vanilloid 1 (TRPV1) with pIC 50 of 7.9, 8.5, 7.9 and 7.7 for TRPV1 from human, rat, canine and guinea pig. JNJ-39729209 inhibits Capsaicin -induced hypotension and inhibit thereby hypothermia. JNJ-39729209 exhibits anti-inflammatory and analgesic activities in Carrageenan - and CFA -induced thermal hyperalgesia rat models. JNJ-39729209 exhibits anti-cough effects in guinea pigs.