K783-0308 is a potent and selective dual inhibitor of FLT3 and MNK2 with IC 50 values of 680 and 406 nM, respectively. K783-0308 inhibits the growth of MOLM-13 (IC 50 =10.5 µM) and MV-4-11 (IC 50 =10.4 µM) cells. K783-0308 promotes acute myeloid leukemia (AML) cell apoptosis and cell cycle arrests in the G0/G1 phase.