K-Ras ligand-Linker Conjugate 1 incorporates a ligand for K-Ras , and a PROTAC linker, which recruit E3 ligases (such as VHL, CRBN, MDM2 , and IAP ). K-Ras ligand-Linker Conjugate 1 can be used in the synthesis of PROTAC K-Ras Degrader-1 , which is potent PROTAC K-Ras degrader that exhibits ≥70% degradation efficacy in SW1573 cells.