计算溶液所需的质量、体积或浓度。
为什么选择此级别
，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
-20°C储存,充氩。超低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
概述
KAG-308 is a potent selective and orally active agonist of EP4 receptor (a prostaglandin E2 receptor subtype), suppresses colitis and promotes histological mucosal healing, potently inhibits TNF-α production. KAG-308 shows a K i and an EC 50 of 2.57 nM and 17 nM for human EP4 receptor, respectively, more selective over EP1, EP2, EP3 and IP receptor
In Vitro
KAG-308 is a potent selective and orally active agonist of EP4 receptor, suppresses colitis and promots histological mucosal healing. KAG-308 shows a K i and EC 50 values of 2.57 nM and 17 nM for human EP4 receptor, respectively, more selective over human EP1 (K i , 1410 nM; EC 50 , 1000 nM), EP2 (K i , 1540 nM; EC 50 , 1000 nM), EP3 (K i , 32.4 nM; EC 50 , 160 nM) and IP receptor (K i , 52.9 nM; EC 50 , >10000 nM). KAG-308 also exhibits potent agonist activity for human and mouse EP4 with an EC 50 of 0.15 nM and 1.0 nM, respectively in the dual luciferase reporter assay. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Form:Solid
IC50& Target:EC50: 17 nM (Human EP4 receptor), 160 nM (Human EP3 receptor), 1000 nM (Human EP2 receptor), 1000 nM (Human EP2 receptor), Ki: 2.57 nM (Human EP4 receptor), 32.4 nM (Human EP3 receptor), 52.9 nM (Human IP receptor), 1410 nM (Human EP1 receptor), 1540 nM (Human EP2 receptor)
规格
英文别名
HY-128686 | (2Z,3aR,4R,5R,6aS)-3,3-Difluorohexahydro-4-[(1E,3R,4R)-3-hydroxy-4-(3-methylphenyl)-1-penten-1-yl]-2-[4-(2H-tetrazol-5-yl)butylidene]-2H-cyclopenta[b]furan-5-ol | 1215192-68-9 | SCHEMBL1651164 | 4-[(Z)-(1S,5R,6R,7R)-6-[(1E,3R,4R)-3-Hydroxy-4-(
英文名称
KAG-308
生化机理
KAG-308 是一种强效的 EP4 受体（前列腺素 E2 受体亚型）选择性口服活性激动剂，可抑制结肠炎并促进组织学粘膜愈合，还能有效抑制 TNF-α 的产生。KAG-308 的 K i 和 EC 50 值分别为 2.57 nM 和 1.
储存条件
-20°C储存,充氩
运输条件
超低温运输
作用类型
激动剂
名称和识别符
分子类型
小分子
IUPAC Name
(2Z,3aR,4R,5R,6aS)-3,3-difluoro-4-[(E,3R,4R)-3-hydroxy-4-(3-methylphenyl)pent-1-enyl]-2-[4-(2H-tetrazol-5-yl)butylidene]-4,5,6,6a-tetrahydro-3aH-cyclopenta[b]furan-5-ol
INCHI
1S/C24H30F2N4O3/c1-14-6-5-7-16(12-14)15(2)18(31)11-10-17-19(32)13-20-23(17)24(25,26)21(33-20)8-3-4-9-22-27-29-30-28-22/h5-8,10-12,15,17-20,23,31-32H,3-4,9,13H2,1-2H3,(H,27,28,29,30)/b11-10+,21-8-/t15-,17+,18-,19-,20+,23-/m1/s1
InChi Key
KSELABKNBIUMGG-YGBAREPYSA-N
Smiles
CC1=CC(=CC=C1)C(C)C(C=CC2C(CC3C2C(C(=CCCCC4=NNN=N4)O3)(F)F)O)O
Isomeric SMILES
CC1=CC(=CC=C1)[C@@H](C)[C@@H](/C=C/[C@H]2[C@@H](C[C@H]3[C@@H]2C(/C(=C/CCCC4=NNN=N4)/O3)(F)F)O)O
PubChem CID
MeSH Entry Terms
3,3-difluorohexahydro-4-((1E,3R,4R)-3-hydroxyl-4-(3-methylphenyl)-1-penten-1-yl)-2-(4-(1H-tetrazol-5-yl)butylidene)-2H-cyclopenta(b)furan-5-ol;KAG-308
分子量
460.52
技术文档
高级数据
三维结构
交互式化学结构模型
化学和物理性质
溶解性
DMSO : 80 mg/mL (173.72 mM; Need ultrasonic) H2O : <0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble)
质检证书(CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
溶液计算器
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