Lw13 is a Hsp90 -targeting PROTAC and achieves maximum degradation at a concentration of 0.05 μM inSiha cells. Lw13 induces cell apoptosis and exhibits potent anti-tumor activity both in vitro and in vivo(Sturcture Note:(Blue: Cereblon ligand , Black: linker;Pink: Hsp90 inhibitor SNX-5422 ).