LY 379196 is a PKC-β inhibitor (IC 50 : 50 nM and 30 nM for PKC βI and βII respectively). LY 379196 inhibits the VEGF , IGF-1 and bFGF-induced proliferation of bovine retinal microvascular endothelial cells (BREC). LY 379196 is an antiproliferatory agentfor proliferative retinopathy.