计算溶液所需的质量、体积或浓度。
有货
为什么选择此级别
Moligand™ 级 ，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
-80℃储存。特低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 202 篇同行评审文献引用。
概述
Levofloxacin is a broad-spectrum antibiotic used in pharmacokinetic , antibiotic resistance , and resistance prevention studies. Antibiotic against bacterial respiratory tract infections.
Information
Levofloxacin (Fluoroquinolone) is a broad-spectrum antibiotictopoisomerase IIandtopoisomerase IVinhibitor, used to treat respiratory, urinary tract, gastrointestinal, and abdominal infections.
In vitro
Levofloxacin is active against most aerobic Gram-positive and Gram-negative organisms and demonstrates moderate\xa0activity\xa0against anaerobes. Levofloxacin is two-fold more active than ciprofloxacin against Streptococcus pneumoniae and 2- to 4-fold more active than ciprofloxacin against Staphylococcus aureus, Xanthomonas maltophilia, and Bacteroides fragilis. Levofloxacin is two- to eightfold more\xa0active\xa0than ciprofloxacin against coagulase-negative staphylococci and Acinetobacter spp., although these improvements in potency may not be clinically relevant.\xa0Levofloxacin\xa0inhibits 90% of streptococci when it is used at concentrations of 1 mg/mL to 2 mg/mL. Levofloxacin\xa0exhibits twofold greater\xa0inhibitory\xa0and\xa0bactericidal\xa0activities\xa0than ofloxacin\xa0against\xa0either extracellular or intracellular tubercle bacilli.\xa0 Levofloxacin\xa0has the least\xa0inhibitory\xa0effect on osteoblastic cell growth, with a 50%\xa0inhibitory concentration of approximately 80 mg/mL at 48 and 72 hours. Levofloxacin results in strong inhibition of calcium deposition, as determined on day 14 by alizarin red staining and biochemical analysis. Levofloxacin inhibits glycosaminoglycan synthesis initially and DNA synthesis and mitochondrial function secondarily at actual arthropathic concentrations in cultured rabbit chondrocytes but that these changes are reversible and not enough to kill the cells.
In vivo
Levofloxacin is as efficacious as or more efficacious than that with ciprofloxacin in systemic as well as pyelonephritis infections in mice. Levofloxacin achieves higher concentrations in the serum and tissue of mice than does ciprofloxacin.
Cell Data
cell lines：
Concentrations：
Incubation Time：
Powder Purity:≥98%
规格
英文别名
Fluoroquinolone | (3S)-9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid
规格或纯度
Moligand™, 10mM in DMSO
英文名称
Levofloxacin
生化机理
左氧氟沙星（氟喹诺酮）是一种广谱抗生素，是拓扑异构酶 II 和拓扑异构酶 IV 抑制剂，用于治疗呼吸道、泌尿道、胃肠道和腹部感染。
储存条件
-80℃储存
运输条件
特低温运输
名称和识别符
EC号
600-146-0
分子类型
小分子
Isomeric SMILES
C[C@H]1COC2=C3N1C=C(C(=O)C3=CC(=C2N4CCN(CC4)C)F)C(=O)O
分子量
361.37
Reaxy-Rn
3657947
Reaxys-RN link address
https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=3657947&ln=
技术文档
高级数据
化学和物理性质
溶解性
Solubility (25°C) In vitro 5%TFA 3.06 mg/mL (13.0 mM); DMSO: 0.5 mg/mL (2.12 mM); Water: Insoluble;
比旋光度
-66° (C=5,CHCl3)
熔点
224 °C
安全和危险性（GHS）
信号词
危险
危险声明
H302: 吞食有害
H317: 可能引起皮肤过敏反应
H334: 吸入可能引起过敏或哮喘病症状或呼吸困难
H361: 怀疑破坏生育力或未出生的孩子
RTECS
UU8815550
Merck Index
6771
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！
| 批号(Lot Number) | 证书类型 | 货号 |
|---|---|---|
 A2310069 |
分析证书 | L407938 |
技术文档和文章
此产品的引用文献
溶液计算器
产品仅提供给经过验证的企业、机构和合格的专业人员用于研发。不适用于人类、动物、诊断或治疗。
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