| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| L408751-1ml |
1ml |
现货  |
|
| 英文别名 | A-65006, AG-1749 | 2-((3-methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl)methylsulfinyl)-1H-benzo[d]imidazole |
|---|---|
| 规格或纯度 | Moligand™, 10mM in DMSO |
| 英文名称 | Lansoprazole |
| 生化机理 | 兰索拉唑（A-65006，AG-1749）是一种质子泵抑制剂（PPI），能与顶细胞 H(+)、K(+)-ATP 酶共价结合。兰索拉唑可防止胃产生胃酸。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 作用类型 | 抑制剂 |
| 作用机制 | 钾转运 ATP 酶抑制剂 |
| 产品介绍 |
Lansoprazole is a ATP4A (H+,K+-ATPase) inhibitor (IC50 = 6.3 μM) that displays antisecretory and antiulcer activity. Inhibits gastric acid secretion (IC50 = 0.09 μM for histamine-induced acid formation) and reduces gastric lesion formation induced by a variety of ulcerative stimuli. Antibacterial against Helicobacter pylori in vitro. Also blocks swelling-dependent chloride channel (ICI swell) in NIH3T3 fibroblasts. Lansoprazole is more potent than omeprazoleA H+,K+-ATPase inhibitor that displays antisecretory activity Information Lansoprazole Lansoprazole (A-65006, AG-1749) is a proton-pump inhibitor (PPI) that binds covalently to parietal cell H(+),K(+)-ATPase . Lansoprazole prevents the stomach from producing gastric acid. Lansoprazole inhibits gastric acid secretion via inhibition of gastric hydrogen/potassium adenosine triphosphatase (H+,K(+)-ATPase), an enzyme of the gastric parietal cell membrane that forms part of the proton pump that performs the final step in the acid secretory process. Lansoprazole binds covalently to parietal cell H+,K(+)-ATPase, rendering it nonfunctional and inhibiting the secretion of gastric acid. Lansoprazole is a strong anti-secretory agent that acts on gastric H+/K+-adenosine triphosphatase (H+/K+ ATPase) of parietal cells. Lansoprazole inhibits the increased expression of vascular adhesion molecules, the activation of neutrophils, and the production of pro-inflammatory cytokines from activated endothelial cells. Lansoprazole induces several genes, including phase II detoxifying enzyme (NADPH-ubiquinone oxidoreductase, glutathione S-transferase) and antioxidant stress proteins (HO-1, thioredoxin reductase, and superoxide dismutase) in gastric epithelial cells. Lansoprazole significantly inhibits the production of CINC-1 from stimulated RGM-1 cells with IL-1β. Lansoprazole up-regulates HO-1 expression throughout Nrf2 in rat gastric epithelial cells, and the up-regulated HO-1 has anti-inflammatory effects. In vivo Lansoprazole inhibits acute inflammatory reactions as well as intestinal mucosal injuries induced by ischemia-reperfusion or indomethacin administration in rats. Lansoprazole significantly inhibits intestinal injuries induced by ischemia-reperfusion or indomethacin. lansoprazole administered exogenously prevents the small intestine against ischemia-reperfusion or indomethacin-induced damage, the action being dependent on its anti-inflammatory and anti-oxidative responses. cell lines：A431, HCC827, NCI-H292, NCI-H358, NCI-H23, NCI-H1299, Calu-6 and NCI-H460 cells Concentrations： Incubation Time： Powder Purity:≥95% |
| ALogP | 3.442 |
|---|---|
| hba_count | 4 |
| HBD Count | 1 |
| Rotatable Bond | 6 |
| 分子类型 | 小分子 |
|---|---|
| Canonical SMILES | CC1=C(OCC(F)(F)F)C=CN=C1C[S](=O)C2=NC3=CC=CC=C3[NH]2 |
| 分子量 | 369.36 |
| Reaxy-Rn | 4333393 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=4333393&ln= |
| DMSO(mg / mL) Max Solubility | 74 |
|---|---|
| DMSO(mM) Max Solubility | 200.35 |
| Water(mg / mL) Max Solubility | <1 |
| Reaxy-Rn | 4333393 |
|---|---|
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=4333393&ln= |
| Concentration(Compounding value) | 9.8-10.2(mmol/L) |
|---|---|
| Appearance(L408751) | Colorless Transparent Liquid |
| 1. Yuhong Liu, Jiali Liang, Jiazhen Wu, Hanbin Chen, Zhenbiao Zhang, Hongmei Yang, Liping Chen, Haiming Chen, Ziren Su, Yucui Li. (2017) Transformation of patchouli alcohol to β-patchoulene by gastric juice: β-patchoulene is more effective in preventing ethanol-induced gastric injury. Scientific Reports, 7 (1): (5591). [PMID:28717228] [10.1038/s41598-017-05996-5] |
| 1. Yuhong Liu, Jiali Liang, Jiazhen Wu, Hanbin Chen, Zhenbiao Zhang, Hongmei Yang, Liping Chen, Haiming Chen, Ziren Su, Yucui Li. (2017) Transformation of patchouli alcohol to β-patchoulene by gastric juice: β-patchoulene is more effective in preventing ethanol-induced gastric injury. Scientific Reports, 7 (1): (5591). [PMID:28717228] [10.1038/s41598-017-05996-5] |
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