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Ladarixin, 白细胞介素-8 受体 B 调节器
有货
为什么选择此级别
Moligand™ 级 ，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
-80℃储存。特低温运输 。请查阅批次 COA 获取详细规格。
质量文档
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文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
概述
Ladarixin (DF 2156A free base) is an orally active, allosteric non-competitive and dual CXCR1 and CXCR2 antagonist. Ladarixin can be used for the research of COPD and asthma.
In Vitro
Ladarixin inhibits human polymorphonuclear leukocyte (PMN) migration to CXCL8 (IC 50 at 0.7 nM). MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Ladarixin (10 mg/kg; p.o. once a day) reduces allergic airway inflammation in a model of single OVA exposure. Ladarixin reduces allergic airway inflammation, remodeling, and bronchial hyperreactivity in a model of chronic OVA exposure . Ladarixin (10 mg/kg; p.o. once a day for 8 days) reduces pulmonary inflammation and fibrosis induced by bleomycin in mice . Ladarixin (10 mg/kg; p.o. once a day for 3 days) protects mice from cigarette smoke-induced exacerbation of influenza-A infection . Ladarixin is also effective in decreasing CXCL8-induced polymorphonuclear leukocyte infiltration in several animal models without a significant dose-related reduction in systemic neutrophil counts. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Mice (cigarette smoke-induced exacerbation of Influenza-A infection model) Dosage: 10 mg/kg Administration: P.o. once a day at days 2, 3 and 4 post-infection Result: Significantly attenuated the exacerbation in lethality and respiratory changes noted in CSFlu group.
规格
别名
拉达日辛
规格或纯度
Moligand™,10mM in DMSO
英文名称
Ladarixin
生化机理
Ladarixin（DF 2156A 游离碱）是一种口服活性异构非竞争性 CXCR1 和 CXCR2 双拮抗剂。拉达立新可用于慢性阻塞性肺病和哮喘的研究。
储存条件
-80℃储存
运输条件
特低温运输
作用类型
调节剂
作用机制
白细胞介素-8 受体 B 调节器
名称和识别符
分子类型
小分子
Isomeric SMILES
C[C@H](C1=CC=C(C=C1)OS(=O)(=O)C(F)(F)F)C(=O)NS(=O)(=O)C
PubChem CID
分子量
375.34
技术文档
高级数据
产品属性
| ALogP | 2 |
|---|
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