Solid–Liquid Equilibrium Modeling and Analysis of Acetylcysteine in 12 Pure Solvents

In this work, the solubility of acetylcysteine in 12 pure solvents (water, methanol, ethanol, n-propanol, isopropanol, n-butanol, isobutanol, dimethylformamide, formamide, ethylene glycol, dimethylacetamide, and dimethyl sulfoxide) was determined using a dynamic method over the temperature range from 278.15 to 323.15 K. The results indicate that the solubility of acetylcysteine increases with increases in temperature. Furthermore, the solubility of acetylcysteine in alcohols decreases with decreasing polarity. These solubility data were compared with predictions generated using the modified Apelblat equation, the λh equation, the Wilson model, and the NRTL model. The modified Apelblat equation generated the most accurate values.