Preparation and antibacterial properties of BCZT-Ag piezoelectric coating on titanium surface for orthopedic implants

The titanium dioxide drug-loaded nanotube coating on titanium alloy surface was helpful to reduce the risk of infection after implantation in vivo. In this work, Ba 0.85 Ca 0.15 Zr 0.1 Ti 0.9 O 3 (marked as BCZT) with piezoelectric effect and Ag nanoparticles with antibacterial effect were introduced into the TiO 2 nanotube coating, and a piezoelectric and antibacterial BCZT-Ag coating was prepared on titanium surface. The drug release rate in the nanotubes was reduced by the design of the coating structure. The results showed that the Ag nanoparticles were uniformly distributed in the BCZT-Ag coating. The piezoelectric coefficient of BCZT-Ag2.5 coating reached 13.0 pC/N. The release of silver ions in the BCZT-Ag coating showed a significant slow release trend compared with that in the TiO 2 nanotube silver-loaded coating. Interestingly, the antibacterial rate of polarized BCZT-Ag2.5 coating reached 99% even after being immersed in simulated body fluids for 7 days. The BCZT-Ag2.5 coating has no osteoblast toxicity, and osteoblasts can adhere to the BCZT-Ag2.5 coating on titanium surface. The BCZT-Ag2.5 also shows good biological activity in the simulated body fluid immersion experiment. The results will provide a new idea and data support for the application of biological piezoelectric silver loaded coating on titanium surface in orthopedic implants.