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Highly Diastereoselective Synthesis and Application of Functionalized 2,3-Dihydrofuran Derivatives from Enynones and Bis(diazo) Compounds

Journal 2023 · IF 3.6 · 发表于 2023 年 12 月 13 日
作者: Yu Zhang,Guisheng Deng
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摘要

A highly efficient Ag(I)-catalyzed cascade Michael addition/cyclization of enynones with 1,3-(bis)diazo compounds has been established, providing functionalized 2,3-dihydrofuran derivatives containing a diazo group and an acetylenic bond with excellent diastereoselectivity. Transformation of the diazo group and hydration of the carbon–carbon triple bond have been performed successfully in different reaction systems.