Effects of 2-Phenylethanol on Controlling the Development of Fusarium graminearum in Wheat

Applying plant-derived fungicides is a safe and sustainable way to control wheat scab. In this study, volatile organic compounds (VOCs) of wheat cultivars with and without the resistance geneFhb1were analyzed by GC-MS, and 2-phenylethanol was screened out. The biocontrol function of 2-phenylethanol onFusarium graminearumwas evaluated in vitro and in vivo. Metabolomics analysis indicated that 2-phenylethanol altered the amino acid pathways ofF. graminearum, affecting its normal life activities. Under SEM and TEM observation, the mycelial morphology changed, and the integrity of the cell membrane was destroyed. Furthermore, 2-phenylethanol could inhibit the production of mycotoxins (DON, 3-ADON, 15-ADON) byF. graminearumand reduce grain contamination. This research provides new ideas for green prevention and control of wheat FHB in the field.Keywords:2-phenylethanol;Fusarium graminearum;volatile organic compounds (VOCs);antifungal mechanism;metabolomics