A Multifunctional Biosensor via MXene Assisted by Conductive Metal–Organic Framework for Healthcare Monitoring

For real-time care of metabolic diseases, it is highly demanded to simultaneously monitor metabolite content and diagnose muscle strength in a rapid and convenient way. However, such a biosensor with integrated functions of detecting chemical and biopotential signals at the same time has seldom been reported. In this work, a multifunctional biosensor, integrating the electrochemical detection of uric acid (UA) and glucose (Glu) in sweat, electrophysiological signal acquisition, and electrostimulation therapy, is designed. Hence, an electrophysiological MOF/MXene electrode is fabricated using highly conductive MXene and porous conductive metal–organic framework (c-MOF, Ni 3 (HITP) 2 ). Compared with commercial Ag/AgCl electrode, MOF/MXene electrode has lower electrode/skin interface impedance, higher stability and signal-to-noise (SNR). By utilizing the high charge storage capacity (CSC) of MOF/MXene electrode, it can realize muscle treatment by electrostimulation. Besides, with abundant active regions of c-MOF, the electrode exhibits excellent electrochemical performance in detecting sweat metabolites. Multimodal signals detected by such integrated biosensors are wirelessly transmitted to a mobile terminal, showing significant potential on muscle theranostics and daily non-invasive monitoring. Additionally, they offer timely nutritional guidance for individuals dealing with hyperuricemia or hyperglycemia.