A Novel Ti3C2/CoNP-NCNTHP Electrochemical Sensor for the Detection of Paracetamol and 4-Aminophenol Simultaneously

In this paper, composites of Ti3C2/ZIF-8/ZIF-67 were obtained through in situ growing ZIF-8/ZIF-67 on Ti3C2 with two-dimensional structure prepared by etching MXene using HF. Furtherly, novel materials of Ti3C2 modified with hollow polyhedrons composed of Co nanoparticles and N-doped carbon nanotube (Ti3C2/CoNP-NCNTHP) was got through derivation with high temperature calcination. The materials were combinations of two-dimensional nanosheets and three-dimensional hollow polyhedras, which were characterized by SEM, TEM, XRD, XPS and EIS. Based on this, a new electrochemical sensor of Ti3C2/CoNP-NCNTHP/GCE was constructed to detect paracetamol (PA) and 4-aminophenol (4-AP) simultaneously. Under optimal conditions, the linear ranges for detection of PA and 4-AP were 0.50–350.00 μM and 0.50–200.00 μM with the limits of detection of 0.05 μM and 0.07 μM, respectively. This proposed sensor has lower detection limits and good linear ranges, which was successfully applied for river water and acetaminophen tablets with good accuracy and has potential prospects for practical applications.