Coaxial microfluidic spinning design produced high strength alginate membranes for antibacterial activity and drug release

Directional drug delivery and sufficient strength are two conditions that need to be met for wound dressing. In this paper, an oriented fibrous alginate membrane with sufficient strength was constructed via coaxial microfluidic spinning, and zeolitic imidazolate framework-8/ascorbic acid was used to realize drug delivery and antibacterial activity. The effects of the process parameters of the coaxial microfluidic spinning on the mechanical properties of the alginate membrane were discussed. In addition, it was found that the antimicrobial activity mechanism of zeolitic imidazolate framework-8 was attributed to the disruptive effect of reactive oxygen species (ROS) on bacteria, and the quantitative amount of generated ROS were evaluated by detecting •OH and H 2 O 2 . Furthermore, a mathematical drug diffusion model was established and showed high consistency with the experimental data (R 2  = 0.99). This study provides a new idea for the preparation of dressing materials with high strength and directional drug delivery and also provides some guidance for the development of coaxial microfluidic spin technology to be used in functional materials for drug release.