Au@MOFs used as peroxidase-like catalytic nanozyme for bacterial infected wound healing through bacterial membranes disruption and protein leakage promotion

Bacterial biofilms often hinder the healing of infected chronic wounds. Hence, it is significant to explore ways to destroy bacterial biofilms. In this work, a photothermal therapy strategy of designing Au clusters modified ZIF-8 MOFs ( [email protected] ) as peroxidase-like catalytic nanozyme was proposed for bacterial infected wound healing. Under near-infrared laser (NIR), the prepared [email protected] present enhanced peroxidase-like activity and excellent photothermal response properties. [email protected] achieved bacterial membrane disruption rate of 66.3% and MRSA clearance rate up to 97%. [email protected] also catalyzed endogenous H 2 O 2 to OH and achieved almost 97.4% healing rate in animal experiments. The prepared [email protected] with peroxidase-like catalytic nanozyme properties has great potential in the treatment of infected diabetic wounds through bacterial membranes disruption and protein leakage promotion.