Improving osteogenic and antibacterial properties of porous titanium scaffolds by facile flow-casting of bioactive glass-Ag@MSN coatings

Modification of porous titanium (PT) implants with biological coatings is being challenged due to their inert surface and complex internal structure. A facile flow-casting technique has been utilized to prepare a bioceramic coating consisting of 45S5 bioactive glass (BG) and core-shelled [email protected] particles homogeneously on the entire surface of PT. The addition of [email protected] nanoparticles facilitated the sintering of BG and subsequently enhanced the adhesion of the coating. Slightly delayed hydroxyapatite formation was also detected probably due to minimized release and consumption of calcium ions . In-vitro assessments of the coating cultured with MC3T3-E1 osteoblasts and Staphylococcus aureus were carried out to assess their potential as multifunctional bone implants with excellent bioactivity and antibacterial properties. A template for producing robust and multi-component ceramic coatings on PT and other porous implants with tailorable biological properties for bone tissue engineering has been established.